Pharma Science Monitor an International Journal of Pharmaceutical Sciences a Review on Mucoadhesive Buccal Patch as a Novel Drug Delivery System

Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, NH-58, Baghpat Road-Bypass Crossing, Meerut-250005 (U.P), India ABSTRACT Drug release from mucoadhesive patches at predetermined rate in oral cavity having distinct advantages over traditional dosage forms as tablets, gels and solutions. This review provides brief information about method of preparation and evaluation of mucoadhesive buccal patches for the controlled systemic delivery of drug by which first pass hepatic metabolism can be avoided. Mucoadhesive buccal patches can be prepared by several methods as solvent casting method, semisolid casting, hot melt extrusion, solid extrusion dispersion and rolling method. After preparation of mucoadhesive patches next phase is evaluation of mucoadhesive patches those are weight variation, patch thickness, % volume entrapment efficiency, measurement of the % elongation at break, surface pH, folding endurance and stability study. A wide number of drugs have already been used in mucoadhesive buccal drug delivery system such as Prochlorperazine maleate, Glipizide, Felodipine, Ibuprofen, Diltiazem hydrochloride, Metoprolol tartrate, Atenolol, Chlorpheniramine maleate.